Given the wide adoption of smartphones, an interesting debate is taking place regarding their optimal screen size and specifically whether possible portability issues counterbalance the obvious benefits of a larger screen. Moreover, the lack of scientific evidence about the concrete impact of mobile phones’ screen size on usability raises questions both to practitioners and researchers. In this paper, we investigate the impact of a mobile phone’s screen size on users’ effectiveness, efficiency and perceived usability as measured using System Usability Scale (SUS). An experiment was conducted with 60 participants, which interacted with the same information seeking application on three different devices of the same brand that differed on their screen size. A significant effect of screen size on efficiency was derived, leading to an important finding that users who interact with larger than 4.3in screens are more efficient during information seeking tasks.